About Me.
Are you asking yourself why you should trust me with your research and bioinformatics data? Find out who I am and reach out to me any time!
Experimental consultant and Data Analyst
Dr. rer. nat Julia Franzen obtained her Bachelor’s and Master’s degree in Molecular Biotechnology at the university of Heidelberg. Her PhD at RWTH Aachen university focused on stem cell biology, epigenetics and ageing, both in the lab and on the computer. After two years as a PostDoc in the same field, she took over the scientific and technical coordination of the Genomics Facility in Aachen. She is experienced in:
- Microarray and sequencing bioinformatics data analysis
- Biomarker detection and validation
- Sequencing library preparation and further wet lab techniques
- Experimental consulting for Genomics Services
You can find My work in these Publications
- Franzen J, et al. DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift. Communications Biology, (2021) 4: 598.
- Franzen J, et al. Epigenetic clocks are not accelerated in COVID-19 patients. International Journal of Molecular Sciences, (2021) 22: 9306.
- Franzen J, et al. Senescence-Associated DNA Methylation is Stochastically Acquired in Subpopulations of Mesenchymal Stem Cells. Aging Cell, 2017, 16: 183-191.
- Franzen J, et al. Epigenetic Modifications upon Senescence of Mesenchymal Stem Cells. Current Stem Cell Reports, 2016; 2: 248–254.
- Božić T, Kuo C-C, Hapala J, Franzen J, et al. Investigation of Measurable Residual Disease in Acute Myeloid Leukemia by DNA Methylation Patterns. Leukemia (2022) 36: 80–89.
- Han Y, Nikolić M, Gobs M, Franzen J, et al. Targeted methods for epigenetic age-predictions in mice. Scientific Reports (2020) 10: 22439.
- Cypris O, Eipel O, Franzen J, et al. PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation. Clinical Epigenetics (2020) 12: 125.
- Fernandez-Rebollo E, Franzen J, et al. Senescence-associated metabolomic phenotype in primary and iPSC-derived mesenchymal stromal cells. Stem Cell Reports (2020) 2: 201-209.
- Han Y, Franzen J, et al. New Targeted Approaches for Epigenetic Age Predictions. BMC Biology (2020) 18: 71.
- Hollmann J, Brecht J, Goetzke R, Franzen J, et al. Genetic Barcoding Reveals Clonal Dominance in iPSC-Derived Mesenchymal Stromal Cells. Stem Cell Research & Therapy (2020) 11: 105
- Goetzke R, Keijdener H, Franzen J, et al. Differentiation of Induced Pluripotent Stem Cells towards Mesenchymal Stromal Cells is Hampered by Culture in 3D Hydrogels. Scientific Reports 2019;9:15578.
- Cypris O, Frobel J, Rai S, Franzen J, et al. Tracking of epigenetic changes during hematopoietic differentiation of induced pluripotent stem cells. Clinical Epigenetics, 2019;11:19.
- Han Y, Eipel M, Franzen J, et al. Epigenetic age-predictor for mice based on three CpG sites. Elife, 2018; 7. pii: e37462.
- Frobel J, Rahmig S, Franzen J, et al. Epigenetic aging of human hematopoietic cells is not accelerated upon transplantation into mice. Clinical Epigenetics, 2018; 10: 67.
- Grezella C, Fernandez-Rebollo E, Franzen J, et al. Effects of Senolytic Drugs on Human Mesenchymal Stromal Cells. Stem Cell Research & Therapy, 2018; 9: 108.
- Zirkel A, Nikolic M, Sofiadis K, Mallm J-P, Brackley CA, Gothe H, Drechsel O, Becker C, Altmüller J, Josipovic N, Georgomanolis T, Brant L, Franzen J, et al. HMGB2 loss upon senescence entry disrupts genomic organization and induces CTCF clustering across cell types. Molecular Cell, 2018; 70: 1-15.
- Goetzke R, Franzen J, et al. Does Soft Really Matter? Differentiation of Induced Pluripotent Stem Cells into Mesenchymal Stromal Cells is Not Influenced by Soft Hydrogels. Biomaterials, 2018; 156: 147-158.
- Fernandez-Rebollo E, Mentrup B, Ebert R, Franzen J, et al. Human Platelet Lysate versus Fetal Calf Serum: These Supplements Do Not Select for Different Mesenchymal Stromal Cells. Scientific Reports, 2017, 7: 5132.
- Kalwa M, Hänzelmann S, Otto S, Kuo Chao-Chung, Franzen J, et al. The lncRNA HOTAIR Impacts on Mesenchymal Stem Cells via Triple Helix Formation. Nucleic Acid Research, 2016; 44: 10631-10643.
- Candio de Almeida D, Ferreira MRP, Franzen J, et al. Epigenetic classification of human mesenchymal stromal cells. Stem Cell Reports, 2016, 6: 168-75.
Making Bioinformatics accessible for everyone
Contact
Heketweg 39
52223 Stolberg
Germany
info@pryzen.de
+49 176 26512668